Gastric band Surgery In France Being overweight may be more harmful than you thought Sign in Log in with your Medical News Today account to create or edit your custom homepage, catch-up on your opinions notifications and set your newsletter preferences. Sign in Register for a free account For FREE No Obligation Information about the cost of Gastric Band Surgery in France Click here Or Click the Image Below to visit our Special offer Page to see if you Qualify for any Discounts Read more……>click Here< Read more... Read more…

Genome-Wide Association Study of Primary Sclerosing Cholangitis Identifies New Risk Primary sclerosing cholangitis (PSC) is a rare progressive disorder leading to bile duct destruction; ∼75% of patients have comorbid inflammatory bowel disease (IBD). We undertook the largest genome-wide association study of PSC (4,796 cases and 19,955 population controls) and identified four new genome-wide significant loci. The most associated SNP at one locus affects splicing and expression of UBASH3A, with the protective allele (C) predicted to cause nonstop-mediated mRNA decay and lower expression of UBASH3A. Further analyses based on common variants suggested that the genome-wide genetic correlation (rG) between PSC and ulcerative colitis (UC) (rG = 0.29) was significantly greater than that between PSC and Crohn’s disease (CD) (rG = 0.04) (P = 2.55 × 10-15). UC and CD were genetically more similar to each other (rG = 0.56) than either was to PSC (P < 1.0 × 10-15). Our study represents a substantial advance in understanding of the genetics of PSC. Read more......>click Here< Read more... Read more…

Figure 1 Functional characterization of Atxn1, Ebf1, Rreb1 and Ube2e2 (a,b,e) Data is displayed as box/whisker plots where the center line represents the median, box limits contain the 25th-75th percentiles, and whiskers span max/min values.(a) Gene expression measured by qPCR in murine subcutaneous (SAT), perigonadal visceral (VAT), and pericardial (PAT) adipose tissues (n=6 mice). Statistical significance was assessed using ANOVA and Sidak’s correction for multiple comparisons.(b) Gene expression measured by qPCR in murine adipose tissues after 8 weeks of high fat feeding compared to normal chow fed controls (n=5 mice per group). Statistical significance was assigned using a two-sided T-test.(c) Gene expression measured by qPCR in cultured adipocyte progenitors isolated from the subcutaneous (SAT) or perigonadal visceral (VAT) depots (n=4 replicates). Cells were expanded to confluence and then collected at intervals after induction of adipogenic differentiation. Data displayed as mean, error bar=s.e.m. Statistical significance was assessed using ANOVA and Sidak’s correction for multiple comparisons to time 0.(d) Oil-red-o staining of progenitors isolated from subcutaneous adipose and exposed to retroviral delivery of shRNA constructs during ex vivo expansion and induction of adipogenesis. Relative to control vector carrying a scramble sequence, shRNA constructs specific for Atxn1 and Ube2e2 impaired adipogenic differentiation. Scale=1mm.(e) Oil-red-o stain was alcohol extracted and quantified at OD520 (n=9 technical replicates). Statistical significance was assessed using ANOVA and Sidak’s correction for multiple comparisons to control (Scramble). Data representative of 3 independent experiments. Read more……>click Here< Read more... Read more…

Gastric band Surgery In France Does living next to a gym lower obesity risk? Sign in Log in with your Medical News Today account to create or edit your custom homepage, catch-up on your opinions notifications and set your newsletter preferences. Sign in Register for a free account For FREE No Obligation Information about the cost of Gastric Band Surgery in France Click here Or Click the Image Below to visit our Special offer Page to see if you Qualify for any Discounts Read more……>click Here< Read more... Read more…

Gastric band Surgery In France Could this device help to prevent the harms of sitting? Sign in Log in with your Medical News Today account to create or edit your custom homepage, catch-up on your opinions notifications and set your newsletter preferences. Sign in Register for a free account For FREE No Obligation Information about the cost of Gastric Band Surgery in France Click here Or Click the Image Below to visit our Special offer Page to see if you Qualify for any Discounts Read more……>click Here< Read more... Read more…

Gastric band Surgery In France Diabetes: New pathway to treatment suggested by protein culprit What is the link between anxiety and diabetes? New research shows that a protein related to the development of anxiety and depression may also play a role in triggering diabetes. Scientists from the Max Planck Institutes hypothesize that an antagonist compound could be used to block its effect. Scientists investigate a new lead in the search for better diabetes treatments. The main known causes for type 2 diabetes so far include obesity and lack of physical exercise – both of which can lead to insulin resistance – as well as a family history of the condition. Insulin resistance occurs when muscles, liver, and fat cells become unable to use insulin appropriately, which ultimately leads to a dangerous rise in blood glucose levels. Now, researchers from the Max Planck Institute of Psychiatry in Munich, Germany, have found that a protein called FKBP51 may also play a role in triggering type 2 diabetes. The protein has so far been associated with anxiety and depression; it contributes to the regulation of the stress system. When the gene that controls the production of FKBP51 suffers a mutation, this can lead to dysregulation of the stress system, which, in turn, can cause mental health disorders. Mathias Schmidt – lead researcher of the current study – and colleagues have recently noted that the FKBP51 protein also contributes to forming a molecular link between the stress system and the regulation of various metabolic functions. This may make FKBP51 responsible for the onset of metabolic diseases such as obesity and diabetes. The team’s findings have now been published in the journal Nature Communications. Protein reacts to metabolic stress Schmidt and team looked at a mouse model to understand the potential role played by FKBP51 in metabolic processes. They studied the effect of a high-fat diet on mice in which the FKBP51 gene was expressed, as well as on knockout mice, in which that gene was inactivated artificially. They found that the knockout mice did not gain weight after exposure to the diet, had better glucose, or blood sugar, tolerance, and had more effective insulin signaling. This allowed the researchers to understand that the FKBP51 protein – regulated by the gene with the same name – affects signaling pathways in skeletal muscles. Since the protein is sensitive to metabolic stress factors, such as high fat intake, it can ultimately lead to blood sugar buildup and insulin resistance. These are the main factors to blame in the development of type 2 diabetes and obesity. “FKBP51 influences a signaling cascade in muscle tissue, which with excessive calorie intake leads to the development of glucose intolerance, i.e., the key indicator of diabetes type 2.” Mathias Schmidt The cause may lead to the treatment Fortunately, this mechanism has also offered the scientists an insight into how they might be able to prevent FKBP51’s response to the

Read more…

Gastric band Surgery In France How can we switch off hunger in the brain? Study sheds light Many of us think that controlling our food cravings and sticking to a diet depend largely on our willpower, but our biology has a different story to tell. Now, new research shows that a complex interplay between calories, digestion hormones, and neurons determines what we eat and when. What happens in our brain when we’re hungry, and is there anything we can do to shut down the feeling? While there may be some eating habits that we can control, our biology determines much of our appetite, and there’s more and more research that confirms this. For instance, at Medical News Today, we have recently reported on a study that identified a class of glial brain cells in our hypothalamus – that is, the appetite-controlling area of our brain – which, when activated by certain nutrients, “tell us” to stop eating. Another recent study found that a hormone called asprosin “turns on” our appetite-stimulating neurons and “turns off” our appetite-suppressing neurons. Now, researchers at the University of Pennsylvania in Philadelphia – led by J. Nicholas Betley, an assistant professor in the Department of Biology in the university’s School of Arts and Sciences – delve deeper into the interplay between our gut and our brain. The researchers looked at what it is that triggers our appetite-stimulating neurons, and – more importantly for our weight management efforts – what it is that switches them off. The findings, which were published in the journal Cell Reports, may change how we think about overeating and obesity and may soon lead to wholly new therapies and weight loss strategies. What are AgRP neurons? The so-called agouti-related protein-expressing neurons (AgRP) are neurons in our hypothalamus that become activated when we are hungry. As Betley explains, “When these neurons are firing, they’re basically telling you, ‘You’d better go get food; you’re starving.'” AgRP neurons are “a sensitive alarm system,” Betley says. But, apart from by eating, is there any other way that you can turn the alarm system off? Previous research led by Betley revealed that AgRP neurons deactivate when rodents eat, but interestingly, also when they see or smell the food. In other words, if you’re at a restaurant, feeling hungry, and waiting impatiently for your food – your AgRP neurons would be firing up in an impatient “chatter,” telling you to eat. But, as soon as the waiter brings the food to you and you can see and smell it, these neurons quickly pipe down. For the new study, however, the team wanted to look more closely at the difference between how these neurons are shut down upon eating, and how they are shut down by the mere sight and smell of incoming food. Nutrients switch off AgRP neurons To do so, Betley and team used in vivo calcium imaging – a method that allows the researchers to track the activity of neurons with a high degree of specificity – to study genetically

Read more…

Gastric band Surgery In France Kids’ movies promote poor diet and stigmatize obesity As innocent as children’s movies may seem to be, new research investigated whether or not they promote positive attitudes toward healthful food and the issues surrounding obesity. However, the opposite seems to be the case. A new study assesses attitudes to food and obesity in children’s movies. Childhood obesity is a growing problem. Recent studies have discovered that 32 percent of 2-19-year-olds are overweight, and 17 percent are obese. Some estimate that by 2025, around 268 million children aged 5-17 will be overweight, globally. This is a huge public health concern. There are many factors involved in the weight gain we see in children in the United States, and these include parenting style, peer influence, advertising, and the fact that we are more sedentary now than we have ever been. Another factor that has consistently been linked with obesity is screen time. The length of time that a child spends looking at a screen is associated with a greater body mass index (BMI). Screen time, BMI, and movie content The link between screen time and BMI may be due to several factors: advertising; “mindless” eating while watching shows; and because it replaces physical activities. A new study – published in the journal Pediatrics – looks at another possible factor: the way that movies influence perceptions of body image and diet. The study asks how frequently obesity-promoting content and weight-stigmatizing messages appeared in children’s movies. It is not yet clear if or how these types of depictions affect children who view them. But earlier work has shown that exposure to sexual themes and depictions of alcohol consumption in the media impacts adolescent behavior, so it is fair to consider that some kind of influence is plausible. In a previous study, the current research group found that: “tigmatizing and obesity-related content was not only present but also prevalent in the majority of the top children’s movies from 2006 to 2010.” Specifically, they found that children’s movies regularly presented sedentary activities and unhealthful foods as the norm, as well as stigmatized obesity. With a steadily increasing public focus on obesity and a reported rise in discrimination, the new study aims to update the previous findings and see whether anything has changed – be it for better or worse. Watching and rating children’s movies The group identified the top-grossing G- and PG-rated movies from 2012 through to August 2015 and asked more than 100 children (aged 9-11) which movies they had watched. The team analyzed 31 movies. Each film was broken down into 10-minute segments and marked by raters. They logged any incidence of “items, behaviors, or activities shown to be associated with adiposity and weight status in children, such as oversized portions, drinking sugar-sweetened beverages, and eating while watching screens.” They also looked out for negative portrayals

Read more…