{"id":2981,"date":"2018-11-10T23:56:16","date_gmt":"2018-11-10T23:56:16","guid":{"rendered":"http:\/\/www.termspec.com\/blog\/?p=2981"},"modified":"2018-11-10T23:56:16","modified_gmt":"2018-11-10T23:56:16","slug":"genome-wide-association-study-of-primary-sclerosing-cholangitis-identifies-new-risk-loci-and-quantifies-the-genetic-relationship-with-inflammatory-bowel-disease","status":"publish","type":"post","link":"https:\/\/www.termspec.com\/blog\/genome-wide-association-study-of-primary-sclerosing-cholangitis-identifies-new-risk-loci-and-quantifies-the-genetic-relationship-with-inflammatory-bowel-disease\/","title":{"rendered":"Genome-Wide Association Study of Primary Sclerosing Cholangitis Identifies New Risk Loci and Quantifies the Genetic Relationship With Inflammatory Bowel Disease."},"content":{"rendered":"<p>Genome-Wide Association Study of Primary Sclerosing Cholangitis Identifies New Risk Primary sclerosing cholangitis (PSC) is a rare progressive disorder leading to bile duct destruction; \u00e2\u02c6\u00bc75% of patients have comorbid inflammatory bowel disease (IBD). We undertook the largest genome-wide association study of PSC (4,796 cases and 19,955 population controls) and identified four new genome-wide significant loci. The most associated SNP at one locus affects splicing and expression of UBASH3A, with the protective allele (C) predicted to cause nonstop-mediated mRNA decay and lower expression of UBASH3A. Further analyses based on common variants suggested that the genome-wide genetic correlation (rG) between PSC and ulcerative colitis (UC) (rG = 0.29) was significantly greater than that between PSC and Crohn&#8217;s disease (CD) (rG = 0.04) (P = 2.55 \u00c3\u2014 10-15). UC and CD were genetically more similar to each other (rG = 0.56) than either was to PSC (P < 1.0 \u00c3\u2014 10-15). Our study represents a substantial advance in understanding of the genetics of PSC. Read more......>click Here< Read more...\n\n<a href=\"https:\/\/gastricbandfrance.surgery\/news\/genome-wide-association-study-of-primary-sclerosing-cholangitis-identifies-new-risk-loci-and-quantifies-the-genetic-relationship-with-inflammatory-bowel-disease.html\/\">Read more&#8230;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Genome-Wide Association Study of Primary Sclerosing Cholangitis Identifies New Risk Primary sclerosing cholangitis (PSC) is a rare progressive disorder leading to bile duct destruction; \u00e2\u02c6\u00bc75% of patients have comorbid inflammatory bowel disease (IBD). We undertook the largest genome-wide association study of PSC (4,796 cases and 19,955 population controls) and identified four new genome-wide significant loci. The most associated SNP at one locus affects splicing and expression of UBASH3A, with the protective allele (C) predicted to cause nonstop-mediated mRNA decay and lower expression of UBASH3A. Further analyses based on common variants suggested that the genome-wide genetic correlation (rG) between PSC and ulcerative colitis (UC) (rG = 0.29) was significantly greater than that between PSC and Crohn&#8217;s disease (CD) (rG = 0.04) (P = 2.55 \u00c3\u2014 10-15). UC and CD were genetically more similar to each other (rG = 0.56) than either was to PSC (P < 1.0 \u00c3\u2014 10-15). Our study represents a substantial advance in understanding of the genetics of PSC. Read more......>click Here< Read more...\n\n<a href=\"https:\/\/gastricbandfrance.surgery\/news\/genome-wide-association-study-of-primary-sclerosing-cholangitis-identifies-new-risk-loci-and-quantifies-the-genetic-relationship-with-inflammatory-bowel-disease.html\/\">Read more&#8230;<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"_uf_show_specific_survey":0,"_uf_disable_surveys":false,"footnotes":""},"categories":[65],"tags":[105],"class_list":["post-2981","post","type-post","status-publish","format-standard","hentry","category-news","tag-news"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.termspec.com\/blog\/wp-json\/wp\/v2\/posts\/2981","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.termspec.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.termspec.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.termspec.com\/blog\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.termspec.com\/blog\/wp-json\/wp\/v2\/comments?post=2981"}],"version-history":[{"count":0,"href":"https:\/\/www.termspec.com\/blog\/wp-json\/wp\/v2\/posts\/2981\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.termspec.com\/blog\/wp-json\/wp\/v2\/media?parent=2981"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.termspec.com\/blog\/wp-json\/wp\/v2\/categories?post=2981"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.termspec.com\/blog\/wp-json\/wp\/v2\/tags?post=2981"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}