{"id":3162,"date":"2019-02-05T21:51:35","date_gmt":"2019-02-05T21:51:35","guid":{"rendered":"http:\/\/www.termspec.com\/blog\/?p=3162"},"modified":"2019-02-05T21:51:35","modified_gmt":"2019-02-05T21:51:35","slug":"adipose-derived-circulating-mirnas-regulate-gene-expression-in-other-tissues","status":"publish","type":"post","link":"https:\/\/www.termspec.com\/blog\/adipose-derived-circulating-mirnas-regulate-gene-expression-in-other-tissues\/","title":{"rendered":"Adipose-Derived Circulating miRNAs Regulate Gene Expression in Other Tissues."},"content":{"rendered":"

1. Krol, J., Loedige, I. & Filipowicz, W. The widespread regulation of microRNA biogenesis, function and decay. Nat. Rev. Genet. 11, 597-610 (2010) 2. Sun, L. et al. Mir193b-365 is essential for brown fat differentiation. Nat. Cell Biol. 13, 958-965 (2011) 3. Trajkovski, M. et al. MicroRNAs 103 and 107 regulate insulin sensitivity. Nature 474, 649-653 (2011) 4. Bartel, D. P. MicroRNAs: target recognition and regulatory functions. Cell 136, 215-233 (2009) 5. Ameres, S. L. & Zamore, P. D. Diversifying microRNA sequence and function. Nat. Rev. Mol. Cell Biol. 14, 475-488 (2013) 6. Arroyo, J. D. et al. Argonaute2 complexes carry a population of circulating microRNAs independent of vesicles in human plasma. Proc. Natl Acad. Sci. USA 108, 5003-5008 (2011) 7. Thery, C., Amigorena, S., Raposo, G. & Clayton, A. Curr Protoc Cell Biol Chapter 3, Unit 3 22 (2006) 8. Gy\u00c3\u00b6rgy, B. et al. Membrane vesicles, current state-of-the-art: emerging role of extracellular vesicles. Cell. Mol. Life Sci. 68, 2667-2688 (2011) 9. Hata, A. & Lieberman, J. Dysregulation of microRNA biogenesis and gene silencing in cancer. Sci. Signal. 8, re3 (2015) 10. Dumortier, O., Hinault, C. & Van Obberghen, E. MicroRNAs and metabolism crosstalk in energy homeostasis. Cell Metab. 18, 312-324 (2013) 11. Arner, E. et al. Adipose tissue microRNAs as regulators of CCL2 production in human obesity. Diabetes 61, 1986-1993 (2012) 12. Capobianco, V. et al. miRNA and protein expression profiles of visceral adipose tissue reveal miR-141\/YWHAG and miR-520e\/RAB11A as two potential miRNA\/protein target pairs associated with severe obesity. J. Proteome Res. 11, 3358-3369 (2012) 13. Caroli, A., Cardillo, M. T., Galea, R. & Biasucci, L. M. Potential therapeutic role of microRNAs in ischemic heart disease. J. Cardiol. 61, 315-320 (2013) 14. Guay, C., Roggli, E., Nesca, V., Jacovetti, C. & Regazzi, R. Diabetes mellitus, a microRNA-related disease? Transl. Res. 157, 253-264 (2011) 15. Mori, M. A. et al. Role of microRNA processing in adipose tissue in stress defense and longevity. Cell Metab. 16, 336-347 (2012) 16. Mori, M. A. et al. Altered miRNA processing disrupts brown\/white adipocyte determination and associates with lipodystrophy. J. Clin. Invest. 124, 3339-3351 (2014) 17. Skog, J. et al. Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers. Nat. Cell Biol. 10, 1470-1476 (2008) 18. Taylor, D. D., Zacharias, W. & Gercel-Taylor, C. Exosome isolation for proteomic analyses and RNA profiling. Methods Mol. Biol. 728, 235-246 (2011) 19. Escola, J. M. et al. Selective enrichment of tetraspan proteins on the internal vesicles of multivesicular endosomes and on exosomes secreted by human B-lymphocytes. J. Biol. Chem. 273, 20121-20127 (1998) 20. F\u00c3\u00a9vrier, B. & Raposo, G. Exosomes: endosomal-derived vesicles shipping extracellular messages. Curr. Opin. Cell Biol. 16, 415-421 (2004) 21. Ortega, F. J. et al. MiRNA expression profile of human<\/p>\n

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1. Krol, J., Loedige, I. & Filipowicz, W. The widespread regulation of microRNA biogenesis, function and decay. Nat. Rev. Genet. 11, 597-610 (2010) 2. Sun, L. et al. Mir193b-365 is essential for brown fat differentiation. Nat. Cell Biol. 13, 958-965 (2011) 3. Trajkovski, M. et al. MicroRNAs 103 and 107 regulate insulin sensitivity. Nature 474, 649-653 (2011) 4. Bartel, D. P. MicroRNAs: target recognition and regulatory functions. Cell 136, 215-233 (2009) 5. Ameres, S. L. & Zamore, P. D. Diversifying microRNA sequence and function. Nat. Rev. Mol. Cell Biol. 14, 475-488 (2013) 6. Arroyo, J. D. et al. Argonaute2 complexes carry a population of circulating microRNAs independent of vesicles in human plasma. Proc. Natl Acad. Sci. USA 108, 5003-5008 (2011) 7. Thery, C., Amigorena, S., Raposo, G. & Clayton, A. Curr Protoc Cell Biol Chapter 3, Unit 3 22 (2006) 8. Gy\u00c3\u00b6rgy, B. et al. Membrane vesicles, current state-of-the-art: emerging role of extracellular vesicles. Cell. Mol. Life Sci. 68, 2667-2688 (2011) 9. Hata, A. & Lieberman, J. Dysregulation of microRNA biogenesis and gene silencing in cancer. Sci. Signal. 8, re3 (2015) 10. Dumortier, O., Hinault, C. & Van Obberghen, E. MicroRNAs and metabolism crosstalk in energy homeostasis. Cell Metab. 18, 312-324 (2013) 11. Arner, E. et al. Adipose tissue microRNAs as regulators of CCL2 production in human obesity. Diabetes 61, 1986-1993 (2012) 12. Capobianco, V. et al. miRNA and protein expression profiles of visceral adipose tissue reveal miR-141\/YWHAG and miR-520e\/RAB11A as two potential miRNA\/protein target pairs associated with severe obesity. J. Proteome Res. 11, 3358-3369 (2012) 13. Caroli, A., Cardillo, M. T., Galea, R. & Biasucci, L. M. Potential therapeutic role of microRNAs in ischemic heart disease. J. Cardiol. 61, 315-320 (2013) 14. Guay, C., Roggli, E., Nesca, V., Jacovetti, C. & Regazzi, R. Diabetes mellitus, a microRNA-related disease? Transl. Res. 157, 253-264 (2011) 15. Mori, M. A. et al. Role of microRNA processing in adipose tissue in stress defense and longevity. Cell Metab. 16, 336-347 (2012) 16. Mori, M. A. et al. Altered miRNA processing disrupts brown\/white adipocyte determination and associates with lipodystrophy. J. Clin. Invest. 124, 3339-3351 (2014) 17. Skog, J. et al. Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers. Nat. Cell Biol. 10, 1470-1476 (2008) 18. Taylor, D. D., Zacharias, W. & Gercel-Taylor, C. Exosome isolation for proteomic analyses and RNA profiling. Methods Mol. Biol. 728, 235-246 (2011) 19. Escola, J. M. et al. Selective enrichment of tetraspan proteins on the internal vesicles of multivesicular endosomes and on exosomes secreted by human B-lymphocytes. J. Biol. Chem. 273, 20121-20127 (1998) 20. F\u00c3\u00a9vrier, B. & Raposo, G. Exosomes: endosomal-derived vesicles shipping extracellular messages. Curr. Opin. Cell Biol. 16, 415-421 (2004) 21. Ortega, F. J. et al. MiRNA expression profile of human<\/p>\n

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